Sarah Libring - Mitochondrial transfer from cancer-associated

Journal article

Kayla F. Goliwas, Sarah Libring, Emily D. Berestesky, Shayan Gholizadeh, S. C. Schwager, A. Frost, T. Gaborski, Jian Zhang, Cynthia A. Reinhart-King
Journal of Cell Science, 2023

Semantic Scholar DOI PubMedCentral PubMed

Cite

APA Click to copy
Goliwas, K. F., Libring, S., Berestesky, E. D., Gholizadeh, S., Schwager, S. C., Frost, A., … Reinhart-King, C. A. (2023). Mitochondrial transfer from cancer-associated fibroblasts increases migration in aggressive breast cancer. Journal of Cell Science.

Chicago/Turabian Click to copy
Goliwas, Kayla F., Sarah Libring, Emily D. Berestesky, Shayan Gholizadeh, S. C. Schwager, A. Frost, T. Gaborski, Jian Zhang, and Cynthia A. Reinhart-King. “Mitochondrial Transfer from Cancer-Associated Fibroblasts Increases Migration in Aggressive Breast Cancer.” Journal of Cell Science (2023).

MLA Click to copy
Goliwas, Kayla F., et al. “Mitochondrial Transfer from Cancer-Associated Fibroblasts Increases Migration in Aggressive Breast Cancer.” Journal of Cell Science, 2023.

BibTeX Click to copy

@article{kayla2023a,
  title = {Mitochondrial transfer from cancer-associated fibroblasts increases migration in aggressive breast cancer},
  year = {2023},
  journal = {Journal of Cell Science},
  author = {Goliwas, Kayla F. and Libring, Sarah and Berestesky, Emily D. and Gholizadeh, Shayan and Schwager, S. C. and Frost, A. and Gaborski, T. and Zhang, Jian and Reinhart-King, Cynthia A.}
}

Abstract

ABSTRACT Cancer-associated fibroblasts (CAFs) have distinct roles within the tumor microenvironment, which can impact the mode and efficacy of tumor cell migration. CAFs are known to increase invasion of less-aggressive breast cancer cells through matrix remodeling and leader–follower dynamics. Here, we demonstrate that CAFs communicate with breast cancer cells through the formation of contact-dependent tunneling nanotubes (TNTs), which allow for the exchange of cargo between cell types. CAF mitochondria are an integral cargo component and are sufficient to increase the 3D migration of cancer cells. This cargo transfer results in an increase in mitochondrial ATP production in cancer cells, whereas it has a negligible impact on glycolytic ATP production. Manually increasing mitochondrial oxidative phosphorylation (OXPHOS) by providing extra substrates for OXPHOS fails to enhance cancer cell migration unless glycolysis is maintained at a constant level. Together, these data indicate that tumor–stromal cell crosstalk via TNTs and the associated metabolic symbiosis is a finely controlled mechanism by which tumor cells co-opt their microenvironment to promote cancer progression and may become a potential therapeutic target.